Three-part inventions: Intracellular signaling and induced proximity

被引：127

作者：

Crabtree, GR

Schreiber, SL

机构：

[1] STANFORD UNIV,HOWARD HUGHES MED INST,SCH MED,DEPT PATHOL,STANFORD,CA 94305

[2] HARVARD UNIV,HOWARD HUGHES MED INST,DEPT CHEM & BIOL CHEM,CAMBRIDGE,MA 02138

[3] HARVARD UNIV,HOWARD HUGHES MED INST,DEPT MOL & CELLULAR BIOL,CAMBRIDGE,MA 02138

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(96)20027-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.

引用

页码：418 / 422

页数：5

共 46 条

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