Poly (ADP-ribosyl)ation and stroke

被引:77
作者
Chiarugi, A [1 ]
机构
[1] Univ Florence, Dept Pharmacol, I-50139 Florence, Italy
关键词
cerebral ischemia; PARP; PARG; poly(ADP-ribose); gene expression; neuroprotection;
D O I
10.1016/j.phrs.2005.02.018
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity affords substantial neuroprotection from ischemic brain injury, This review strictly focuses on literature on poly (ADP-ribosyl)ation and ischemic stroke, highlighting the pathogenetic role of poly(ADP-ribose) in ischernic neuronal death, and the therapeutic relevance of drugs modulating its metabolism to pharmacological treatment of cerebral ischemia. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:15 / 24
页数:10
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