Substrates of DNA polymerases with planar conformation of sugar: model of substrate transition state?

被引：8

作者：

Krayevsky, AA

Watanabe, KA

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 117984, Russia

[2] Codon Pharmaceut Inc, Gaithersburg, MD 20877 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 07期

关键词：

D O I：

10.1080/07328319808004228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several years ago, we published an hypothesis concerning conformation of the glycone moiety of different substrates in active centers of several DNA metabolizing enzymes (Nucleosides & Nucleotides 1993, 12, 649-670). This hypothesis prompted us to further study the subtle conformational changes on substrates of DNA polymerases. Data collected in our, as well as other laboratories, have been analyzed, and models of active centers of different DNA polymerases are discussed below. Based on the model of substrate requirements, we now can divide DNA polymerases into two distinguished classes.

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页码：1153 / 1162

页数：10

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