Aptamer based reversible DNA induced hydrogel system for molecular recognition and separation

被引：56

作者：

He, Xiaojin ^{[1
]}

Weiz, Bryan ^{[1
]}

Mi, Yongli ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem & Biomol Engn, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 34期

关键词：

TARGETED DRUG-DELIVERY; MECHANICAL-PROPERTIES; RESPONSIVE HYDROGELS; TRANSITION; CONJUGATE; PLATFORM; RELEASE; LIGANDS; PROBES; CELLS;

D O I：

10.1039/c0cc01392g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An aptamer-based DNA strand, captured with a specific molecule from a multi-species system, was used to initiate crosslinking of the hydrogel. The hydrogel can then be dissolved with a displacement of the DNA strand and the captured molecule can be released. Recognition and separation at the molecular level is thus achieved.

引用

页码：6308 / 6310

页数：3

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