Five new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

被引：51

作者：

Dai, Sheng-Jun ^{[1
]}

Wang, Gong-Fu ^{[1
]}

Chen, Meng ^{[1
]}

Liu, Ke ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 08期

关键词：

Scutellaria barbata; labiatae; neo-clerodane diterpenoid alkaloid; scutebarbatine G; scutebarbatine H; cytotoxic activity;

D O I：

10.1248/cpb.55.1218

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G (1), 6,7-di-O-nicotinoyiscutebarbatine G (2), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (3), scutebarbatine H (4) and 7-O-nicotinoylscutebarbatine H (5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were elucidated by spectroscopic methods including extensive ID and 2D NMR analyses. In vitro, compounds 1-5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC50 values in the range 3.4-8.5 mu m.

引用

页码：1218 / 1221

页数：4

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