Practical synthesis of (Z)-polyaromatic and heteroaromatic vinylacetylenes

被引：18

作者：

Hayford, A ^{[1
]}

Kaloko, J ^{[1
]}

El-Kazaz, S ^{[1
]}

Bass, G ^{[1
]}

Harrison, C ^{[1
]}

Corprew, T ^{[1
]}

机构：

[1] E Carolina Univ, Thomas Harriot Coll Arts & Sci, Dept Chem, Greenville, NC 27858 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol0508173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two synthetic routes to several (Z)-polyaromatic and heteroaromatic substituted vinylacetylenes are described. The nature of aryl- or heteroaryl-substituted carboxaldehyde used as starting material dictated the choice of Wittig salt employed. A very attractive way to construct polyaromatic and pyridine-containing enynes is the reaction of polyaromatic and pyridine-containing aldehydes with bromomethyltriphenylphosphonium bromide in the presence of potassium tert-butoxide followed by a Sonogashira desilylation procedure (method B).

引用

页码：2671 / 2673

页数：3

共 32 条

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