Practical synthesis of (Z)-polyaromatic and heteroaromatic vinylacetylenes

被引:18
作者
Hayford, A [1 ]
Kaloko, J [1 ]
El-Kazaz, S [1 ]
Bass, G [1 ]
Harrison, C [1 ]
Corprew, T [1 ]
机构
[1] E Carolina Univ, Thomas Harriot Coll Arts & Sci, Dept Chem, Greenville, NC 27858 USA
关键词
D O I
10.1021/ol0508173
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two synthetic routes to several (Z)-polyaromatic and heteroaromatic substituted vinylacetylenes are described. The nature of aryl- or heteroaryl-substituted carboxaldehyde used as starting material dictated the choice of Wittig salt employed. A very attractive way to construct polyaromatic and pyridine-containing enynes is the reaction of polyaromatic and pyridine-containing aldehydes with bromomethyltriphenylphosphonium bromide in the presence of potassium tert-butoxide followed by a Sonogashira desilylation procedure (method B).
引用
收藏
页码:2671 / 2673
页数:3
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