Current and upcoming therapies to modulate skin scarring and fibrosis

被引：139

作者：

Coentro, Joao Q. ^{[1
,2
]}

Pugliese, Eugenia ^{[1
,2
]}

Hanley, Geoffrey ^{[1
,2
]}

Raghunath, Michael ^{[3
]}

Zeugolis, Dimitrios I. ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Galway NUI, Regenerat Modular & Dev Engn Lab REMODEL, Biomed Sci Bldg, Galway, Ireland

[2] Natl Univ Ireland Galway NUI, SFI, Ctr Res Med Devices CURAM, Galway, Ireland

[3] Zurich Univ Appl Sci ZHAW, Inst Chem & Biotechnol ICBT, Ctr Cell Biol & Tissue Engn, Wadenswil, Switzerland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2019年 / 146卷

基金：

爱尔兰科学基金会; 欧盟地平线“2020”;

关键词：

Hypertrophic scars; Keloid; Scleroderma; Systemic sclerosis; Myofibroblasts; Scarring; Collagen synthesis; Collagen deposition; Inflammation; Wound healing; Remodelling; GROWTH-FACTOR-BETA; INTRALESIONAL TRIAMCINOLONE ACETONIDE; SELECTIVE NONPEPTIDIC INHIBITORS; HISTONE DEACETYLASE INHIBITORS; POTENTIAL THERAPEUTIC TARGET; DECREASES COLLAGEN-SYNTHESIS; PROCOLLAGEN C-PROTEINASE; FIBROBLASTS IN-VITRO; HYPERTROPHIC SCARS; SYSTEMIC-SCLEROSIS;

D O I：

10.1016/j.addr.2018.08.009

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation. Thus, scarring can also be induced in the dermis, in the absence of an actual wound, during chronic inflammatory processes. Considering the significant portion of the population that is subject to abnormal scarring, this review critically discusses the state-of-the-art and upcoming therapies in skin scarring and fibrosis. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：37 / 59

页数：23

共 387 条

[1]

Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis [J].