Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

被引：292

作者：

Gotter, J ^{[1
]}

Brors, B ^{[1
]}

Hergenhahn, M ^{[1
]}

Kyewski, B ^{[1
]}

机构：

[1] German Canc Res Ctr, Tumor Immunol Program, Div Cellular & Immunol, D-69120 Heidelberg, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 199卷 / 02期

关键词：

self-tolerance; autoimmunity; tumor antigens; epigenetics; gene array;

D O I：

10.1084/jem.20031677

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in annual studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells over-express a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.

引用

页码：155 / 166

页数：12

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