The role of nuclear architecture in genomic instability and ageing

被引：207

作者：

Oberdoerffer, Philipp ^{[1
]}

Sinclair, David A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Paul F Glenn Labs Biol Mech Aging, Boston, MA USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2238

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotes come in many shapes and sizes, yet one thing that they all seem to share is a decline in vitality and health over time - a process known as ageing. If there are conserved causes of ageing, they may be traced back to common biological structures that are inherently difficult to maintain throughout life. One such structure is chromatin, the DNA - protein complex that stabilizes the genome and dictates gene expression. Studies in the budding yeast Saccharomyces cerevisiae have pointed to chromatin reorganization as a main contributor to ageing in that species, which raises the possibility that similar processes underlie ageing in more complex organisms.

引用

页码：692 / 702

页数：11

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