Anti-inflammatory Effect of Microalgal Extracts from Tetraselmis suecica

被引：16

作者：

Jo, Wol Soon ^{[2
]}

Choi, Yoo Jin ^{[2
]}

Kim, Hyoun Ji ^{[2
]}

Nam, Byung Hyouk ^{[3
]}

Hong, Sook Hee ^{[1
]}

Lee, Gye An ^{[4
]}

Lee, Sang Wha ^{[1
]}

Seo, Su Yeong ^{[1
]}

Jeong, Min Ho ^{[1
]}

机构：

[1] Dong A Univ, Dept Microbiol, Coll Med, Pusan 604714, South Korea

[2] Dong Nam Inst Radiol & Med Sci, Pusan 619953, South Korea

[3] Pusan Natl Univ, Dept Microbiol, Coll Nat Sci, Pusan 609735, South Korea

[4] NLP Co Ltd, Pusan 619912, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2010年 / 19卷 / 06期

关键词：

Tetraselmis suecica; lipopolysaccharides (LPS); RAW; 264.7; macrophage; anti-inflammatory activity; nitric oxide; pro-inflammatory cytokine; SCAVENGING ACTIVITIES; CYTOTOXICITY;

D O I：

10.1007/s10068-010-0216-6

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The aim of the present study was to examine the anti-inflammatory activities of extracts from Tetraselmis suecica with respect to nitric oxide (NO) production, tumor necrosis factor (TNF)-alpha and interlukin (IL)-6 release in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. We prepared methanolic extracts and water extract using protease. Of all the prepared extracts, 80% methanol extract exhibited the strongest anti-inflammatory effect. Thus, we further characterized the hexane fraction (He-TS) and ethyl acetate fraction (EA-TS) that contained potential bioactive compounds from the 80M-TS fraction of T suecica. Both He-TS and EA-TS fractions resulted in a significant and dose-dependent inhibition of LPS-induced NO production, TNF-alpha, and IL-6 release (p<0.05). This strong inhibition of various inflammatory mediators such as NO, TNF-alpha, and IL-6 by EA-TS fraction from T suecica suggests that this fraction might contain a potential bioactive compound that would be a good candidate for the development therapeutic anti inflammatory agent.

引用

页码：1519 / 1528

页数：10

共 25 条

[1]

Innate immunity and toll-like receptors: Clinical implications of basic science research [J].