The first synthesis of the Streptomyces derived antibiotic U-62162

被引:7
作者
Alcaraz, L [1 ]
Taylor, RJK [1 ]
机构
[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England
关键词
D O I
10.1039/a801265b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
U-62162, a member of the manumycin family of antibiotics, has been prepared as a mixture of diastereoisomers and shown to contain a syn-hydroxy epoxide nucleus and a 1,3-syn-disposed dimethyl unit in the upper side chain; the cornerstone of the synthetic route utilises organometallic addition to a monoprotected quinone epoxide-the first time this approach has been successfully employed to prepare a manumycin antibiotic.
引用
收藏
页码:1157 / 1158
页数:2
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