Unique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis

被引：83

作者：

Ernst, Robert K. ^{[1
]}

Moskowitz, Samuel M. ^{[1
]}

Emerson, Julia C. ^{[1
]}

Kraig, Gretchen M. ^{[1
]}

Adams, Kristin N. ^{[1
]}

Harvey, Megan D. ^{[1
]}

Ramsey, Bonnie ^{[1
]}

Speert, David P. ^{[1
]}

Burns, Jane L. ^{[1
]}

Miller, Samuel I. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷 / 07期

关键词：

D O I：

10.1086/521367

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three structural features of lipid A ( addition of palmitate [C16 fatty acid], addition of aminoarabinose [ positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n = 86), from the environment (n = 13), and from patients with other conditions (n = 13). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3- hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.

引用

页码：1088 / 1092

页数：5

共 16 条

[11] PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A [J].