The carboxy terminal domain of RNA polymerase II and alternative splicing

被引：109

作者：

Munoz, Manuel J. ^{[1
]}

de la Mata, Manuel ^{[1
]}

Kornblihtt, Alberto R. ^{[1
]}

机构：

[1] Univ Buenos Aires, Lab Fisiol & Biol Mol, Dept Fisiol Biol Mol & Celular, IFIBYNE CONICET, Buenos Aires, DF, Argentina

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2010年 / 35卷 / 09期

关键词：

PRE-MESSENGER-RNA; IN-SITU TRANSCRIPTION; SR PROTEIN FAMILY; MAMMALIAN-CELLS; LARGE SUBUNIT; HUMAN-DISEASE; ELONGATION; CHROMATIN; IICTD; GENE;

D O I：

10.1016/j.tibs.2010.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process.

引用

页码：497 / 504

页数：8

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