Development of a General Palladium-Catalyzed Carbonylative Heck Reaction of Aryl Halides

被引：210

作者：

Wu, Xiao-Feng ^{[1
]}

Neumann, Helfried ^{[1
]}

Spannenberg, Anke ^{[1
]}

Schulz, Thomas ^{[1
]}

Jiao, Haijun ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 41期

关键词：

HETEROARYL BROMIDES; BOND FORMATION; CO-ETHYLENE; COMPLEXES; EFFICIENT; FORMYLATION; CYCLIZATION; ANTICANCER; INDANONES; ALDEHYDES;

D O I：

10.1021/ja1059922

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence of CO has been developed. Applying a catalyst system consisting of [(cinnamyl)PdCl](2) and bulky imidazolylphosphine ligand L1 allows for the efficient and selective synthesis of alpha,beta-unsaturated ketones under mild reaction conditions. Starting from easily available aryl halides and olefins, versatile building blocks can be prepared in a straightforward manner. The generality and functional group tolerance of this novel protocol is demonstrated.

引用

页码：14596 / 14602

页数：7

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