The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

被引：121

作者：

Bertrand, Helene

Monchaud, David

De Cian, Anne

Guillot, Regis

Mergny, Jean-Louis

Teulade-Fichou, Marie-Paule

机构：

[1] Univ Paris 11, CNRS UMR176, Inst Curie, Sect Rech, F-91405 Orsay, France

[2] Museum Natl Hist Nat USM 503, CNRS, UMR 5153, INSERM,U565, F-75005 Paris, France

[3] Univ Paris 11, CNRS, UMR8182, Inst Chim Mol & Mat Orsay, F-91405 Orsay, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 16期

关键词：

SUPRAMOLECULAR CHEMISTRY; TELOMERASE INHIBITOR; CHEMICAL NUCLEASES; IN-VITRO; LIGANDS; TELOMESTATIN; BINDING; STABILIZATION; CELLS; DISSOCIATION;

D O I：

10.1039/b708635k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of terpyridine metallo- organic complexes has been designed and its recognition properties of G- quadruplex-DNA investigated. The series combines easy synthetic access and good affinity - selectivity ratio for quadruplex- DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex- DNA.

引用

收藏

页码：2555 / 2559

页数：5

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