p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation

被引：46

作者：

Kumar, BRP ^{[1
]}

Swaminathan, V ^{[1
]}

Banerjee, S ^{[1
]}

Kundu, TK ^{[1
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, Mol Biol & Genet Unit, Transcript & Dis Lab, Bangalore 560064, Karnataka, India

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2001年 / 276卷 / 20期

关键词：

D O I：

10.1074/jbc.M100934200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human positive coactivator 4 (PC4) acts as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation, We report here that PC4 can be acetylated specifically by another coactivator, p300, Interestingly, phosphorylation of PC4 by casein kinase II inhibits the p300-mediated acetylation, Mass spectral analysis revealed that there are at least two lysine residues acetylated in PC4, as a result of which its DNA binding activity is stimulated.

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页码：16804 / 16809

页数：6

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