Prolactin: The forgotten hormone of human breast cancer

被引：70

作者：

Vonderhaar, BK ^{[1
]}

机构：

[1] NCI, Tumor Immunol & Biol Lab, Mol & Cellular Endocrinol Sect, NIH, Bethesda, MD 20892 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1998年 / 79卷 / 02期

关键词：

prolactin; prolactin receptors; mammary gland; human breast cancer; tamoxifen; antilactogen binding site;

D O I：

10.1016/S0163-7258(98)00017-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prolactin (PRL) is both a mitogen and a differentiating agent in the mammary gland. It has been shown to be involved in mammary cancer development in rodents, but in human breast cancer, its role has long been overlooked. Three criteria are applied to demonstrate PRL's involvement in this disease: (1) PRL receptors are present in human breast cancer cells, (2) human breast cancer cells in culture respond to PRL as a mitogen, and (3) PRL is synthesized by human breast cancer cells and inhibition of the binding of PRL to its receptors inhibits cell growth. PHARMACOL. THER. 79(2):169-178, 1998. (C) 1998 Elsevier Science Inc.

引用

页码：169 / 178

页数：10

共 93 条

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