Prolactin: The forgotten hormone of human breast cancer

被引：70

作者：

Vonderhaar, BK ^{[1
]}

机构：

[1] NCI, Tumor Immunol & Biol Lab, Mol & Cellular Endocrinol Sect, NIH, Bethesda, MD 20892 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1998年 / 79卷 / 02期

关键词：

prolactin; prolactin receptors; mammary gland; human breast cancer; tamoxifen; antilactogen binding site;

D O I：

10.1016/S0163-7258(98)00017-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prolactin (PRL) is both a mitogen and a differentiating agent in the mammary gland. It has been shown to be involved in mammary cancer development in rodents, but in human breast cancer, its role has long been overlooked. Three criteria are applied to demonstrate PRL's involvement in this disease: (1) PRL receptors are present in human breast cancer cells, (2) human breast cancer cells in culture respond to PRL as a mitogen, and (3) PRL is synthesized by human breast cancer cells and inhibition of the binding of PRL to its receptors inhibits cell growth. PHARMACOL. THER. 79(2):169-178, 1998. (C) 1998 Elsevier Science Inc.

引用

页码：169 / 178

页数：10

共 93 条

[21] CLEVENGER CV, 1995, AM J PATHOL, V146, P695
[22] HISTOLOGY AND CYTOMETRICS IN HUMAN-BREAST CANCERS ASSAYED FOR THE PRESENCE OF PROLACTIN RECEPTORS
CODEGONE, ML
DICARLO, R
MUCCIOLI, G
BUSSOLATI, G
[J]. TUMORI JOURNAL, 1981, 67 (06): : 549 - 552
[23] ANTIESTROGENS INDUCE THE SECRETION OF ACTIVE TRANSFORMING GROWTH-FACTOR-BETA FROM HUMAN FETAL FIBROBLASTS
COLLETTA, AA
WAKEFIELD, LM
HOWELL, FV
VANROOZENDAAL, KEP
DANIELPOUR, D
EBBS, SR
SPORN, MB
BAUM, M
[J]. BRITISH JOURNAL OF CANCER, 1990, 62 (03) : 405 - 409
[24] TRANSDUCTION OF PROLACTINS (PRL) GROWTH SIGNAL THROUGH BOTH LONG AND SHORT FORMS OF THE PRL RECEPTOR
DAS, R
VONDERHAAR, BK
[J]. MOLECULAR ENDOCRINOLOGY, 1995, 9 (12) : 1750 - 1759
[25] DAS R, 1994, PROCEEDINGS OF THE XVI INTERNATIONAL CANCER CONGRESS - FREE PAPERS AND POSTERS, TOMES 1-4, P1487
[26] Tamoxifen inhibits prolactin signal transduction in ER - NOG-8 mammary epithelial cells
Das, R
Vonderhaar, BK
[J]. CANCER LETTERS, 1997, 116 (01) : 41 - 46
[27] DAS RB, 1993, MOL CELL ENDOCRINOL, V98, P1
[28] G120R, A HUMAN GROWTH-HORMONE ANTAGONIST, SHOWS ZINC-DEPENDENT AGONIST AND ANTAGONIST ACTIVITY ON NB2 CELLS
DATTANI, MT
HINDMARSH, PC
BROOK, CGD
ROBINSON, ICAF
KOPCHICK, JJ
MARSHALL, NJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (16) : 9222 - 9226
[29] PROLACTIN RECEPTOR DOES NOT CORRELATE WITH ESTROGEN AND PROGESTERONE RECEPTORS IN PRIMARY BREAST-CANCER AND LACKS PROGNOSTIC-SIGNIFICANCE - 10 YEAR RESULTS OF THE NAPLES ADJUVANT (GUN) STUDY
DEPLACIDO, S
GALLO, C
PERRONE, F
MARINELLI, A
PAGLIARULO, C
CARLOMAGNO, C
PETRELLA, G
DISTRIA, M
DELRIO, G
BIANCO, AR
[J]. BRITISH JOURNAL OF CANCER, 1990, 62 (04) : 643 - 646
[30] PROLACTIN STIMULATION OF PROTEIN-KINASE-C IN ISOLATED MOUSE MAMMARY-GLAND NUCLEI
FAN, G
RILLEMA, JA
[J]. HORMONE AND METABOLIC RESEARCH, 1993, 25 (11) : 564 - 568

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