An approach to the skeleton of the Securinega alkaloids.: The total synthesis of (±)-securinine

被引：69

作者：

Liras, S ^{[1
]}

Davoren, JE ^{[1
]}

Bordner, J ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 05期

关键词：

D O I：

10.1021/ol0070482

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.

引用

页码：703 / 706

页数：4

共 25 条

[21] TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE(TMSOTF) CATALYZED AMIDOALKYLATION OF SILYLENOLETHERS - STEREOCONTROLLED SYNTHESES OF (+/-)-SEDAMINE AND (+/-)-NORSEDAMINE [J].