Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function

被引：47

作者：

Georgianna, Wesleigh E. ^{[1
]}

Lusic, Hrvoje ^{[1
]}

Mclver, Andrew L. ^{[1
]}

Deiters, Alexander ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

BIOCONJUGATE CHEMISTRY | 2010年 / 21卷 / 08期

关键词：

PHOTOCHEMICAL CONTROL; DRUG-DELIVERY; PEGYLATION; LYSOZYME; EXPRESSION; MOLECULES; CHEMISTRY;

D O I：

10.1021/bc100084n

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

PEGylation is commonly employed to enhance the pharmacokinetic properties of proteins, but it can interfere with natural protein function. Protein activity can thus be abrogated through PEGylation, and a controllable means to remove the polyethylene glycol (PEG) group from the protein is desirable. As such, light affords a unique control over biomolecules through the application of photosensitive groups. Herein, we report the synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity.

引用

页码：1404 / 1407

页数：4

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