1,3-dihydrobenzolclfuran nucleoside analogues:: Additional studies of the thymine derivative

被引：13

作者：

Egron, D

Périgaud, C

Gosselin, G

Aubertin, AM

Faraj, A

Sélouane, M

Postel, D

Len, C ^{[1
]}

机构：

[1] Univ Picardie, Lab Glucides, F-80039 Amiens, France

[2] Univ Montpellier 2, Lab Cooperat Idenix, CNRS, F-34095 Montpellier 5, France

[3] Fac Med Strasbourg, Inst Virol, INSERM, U74, F-67000 Strasbourg, France

[4] Univ Montpellier 2, UMR 5625 CNRS, F-34095 Montpellier 5, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.09.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5'-triphosphate derivative to interact efficiently with the reverse transcriptase. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：4473 / 4475

页数：3

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