Does the membrane's physical state control the expression of heat shock and other genes?

被引:309
作者
Vigh, L
Maresca, B
Harwood, JL
机构
[1] Hungarian Acad Sci, Biol Res Ctr, H-6701 Szeged, Hungary
[2] CNR, Int Inst Genet & Biophys, I-80125 Naples, Italy
[3] Cardiff Univ, Sch Biosci, Cardiff CF1 3US, S Glam, Wales
关键词
D O I
10.1016/S0968-0004(98)01279-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Membranes provide the structural framework that divides cells from their environment and that, in eukaryotic cells, permits compartmentation. They are not simply passive barriers that are liable to be damaged during environmental challenge or pathological states, but are involved in cellular responses and in modulating intracellular signalling. Recent data show that the expression of several genes, particularly those that respond to changes in temperature, ageing or disease, is influenced and/or controlled by the membrane's physical state.
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页码:369 / 374
页数:6
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