First regioselective ortho-lithiation induced by a 2-chloropyridyl group complexation

被引：25

作者：

Fort, Y ^{[1
]}

Rodrigues, AL ^{[1
]}

机构：

[1] Univ Nancy 1, UMR CNRS 7565, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 12期

关键词：

D O I：

10.1021/jo026788g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It is shown that t-BuLi in Et2O promotes an exclusive regioselective metalation of 2-aryl-6-chloropyridine compounds at the aromatic ortho position demonstrating that the 2-chloropyridyl moiety may be considered as a directing group. This functionally directed metalation group was successfully used for the selective lithiation of substituted aromatics and for the straightforward preparation of new N,P ligands.

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页码：4918 / 4922

页数：5

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