Caspases: key mediators of apoptosis

被引：386

作者：

Thornberry, NA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(98)90615-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.

引用

页码：R97 / R103

页数：7

共 32 条

[1] ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE
BLACK, RA
KRONHEIM, SR
SLEATH, PR
[J]. FEBS LETTERS, 1989, 247 (02) : 386 - 390
[2] INHIBITION OF ICE FAMILY PROTEASES BY BACULOVIRUS ANTIAPOPTOTIC PROTEIN P35
BUMP, NJ
HACKETT, M
HUGUNIN, M
SESHAGIRI, S
BRADY, K
CHEN, P
FERENZ, C
FRANKLIN, S
GHAYUR, T
LI, P
LICARI, P
MANKOVICH, J
SHI, LF
GREENBERG, AH
MILLER, LK
WONG, WW
[J]. SCIENCE, 1995, 269 (5232) : 1885 - 1888
[3] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME
CERRETTI, DP
KOZLOSKY, CJ
MOSLEY, B
NELSON, N
VANNESS, K
GREENSTREET, TA
MARCH, CJ
KRONHEIM, SR
DRUCK, T
CANNIZZARO, LA
HUEBNER, K
BLACK, RA
[J]. SCIENCE, 1992, 256 (5053) : 97 - 100
[4] X-linked IAP is a direct inhibitor of cell-death proteases
Deveraux, QL
Takahashi, R
Salvesen, GS
Reed, JC
[J]. NATURE, 1997, 388 (6639) : 300 - 304
[5] Pyridazinodiazepines as a high-affinity, P-2-P-3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor
Dolle, RE
Prasad, CVC
Prouty, CP
Salvino, JM
Awad, MMA
Schmidt, SJ
Hoyer, D
Ross, TM
Graybill, TL
Speier, GJ
Uhl, J
Miller, BE
Helaszek, CT
Ator, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (13) : 1941 - 1946
[6] First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme
Dolle, RE
Prouty, CP
Prasad, CVC
Cook, E
Saha, A
Ross, TM
Salvino, JM
Helaszek, CT
Ator, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (13) : 2438 - 2440
[7] MECHANISMS AND FUNCTIONS OF CELL-DEATH
ELLIS, RE
YUAN, JY
HORVITZ, HR
[J]. ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 : 663 - 698
[8] HOWARD AD, 1991, J IMMUNOL, V147, P2964
[9] IDENTIFICATION OF A MONOCYTE SPECIFIC PRE-INTERLEUKIN 1-BETA CONVERTASE ACTIVITY
KOSTURA, MJ
TOCCI, MJ
LIMJUCO, G
CHIN, J
CAMERON, P
HILLMAN, AG
CHARTRAIN, NA
SCHMIDT, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5227 - 5231
[10] PEPTIDYL (ACYLOXY)METHYL KETONES AND THE QUIESCENT AFFINITY LABEL CONCEPT - THE DEPARTING GROUP AS A VARIABLE STRUCTURAL ELEMENT IN THE DESIGN OF INACTIVATORS OF CYSTEINE PROTEINASES
KRANTZ, A
COPP, LJ
COLES, PJ
SMITH, RA
HEARD, SB
[J]. BIOCHEMISTRY, 1991, 30 (19) : 4678 - 4687

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