Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

被引：320

作者：

Boureau, Y-Lan ^{[2
]}

Dayan, Peter ^{[1
]}

机构：

[1] UCL, Gatsby Computat Neurosci Unit, London WCIN 3AR, England

[2] NYU, Courant Inst Math Sci, New York, NY USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2011年 / 36卷 / 01期

关键词：

dopamine; norepinephrine; opponency; psychiatry and behavioral sciences; reinforcement learning; serotonin; MEDIAL PREFRONTAL CORTEX; DORSAL RAPHE NUCLEUS; VENTRAL TEGMENTAL AREA; PAVLOVIAN-INSTRUMENTAL TRANSFER; ANTERIOR CINGULATE CORTEX; IN-VIVO MICRODIALYSIS; BASOLATERAL AMYGDALA NEURONS; 5-HT2C RECEPTOR ANTAGONISTS; MEDIUM SPINY NEURONS; CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION;

D O I：

10.1038/npp.2010.151

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Affective valence lies on a spectrum ranging from punishment to reward. The coding of such spectra in the brain almost always involves opponency between pairs of systems or structures. There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. In this review, we consider the structure of opponency in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may thus arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition. We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine. Neuropsychopharmacology Reviews (2011) 36, 74-97; doi: 10.1038/npp.2010.151; published online 29 September 2010

引用

页码：74 / 97

页数：24

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