Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

被引：320

作者：

Boureau, Y-Lan ^{[2
]}

Dayan, Peter ^{[1
]}

机构：

[1] UCL, Gatsby Computat Neurosci Unit, London WCIN 3AR, England

[2] NYU, Courant Inst Math Sci, New York, NY USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2011年 / 36卷 / 01期

关键词：

dopamine; norepinephrine; opponency; psychiatry and behavioral sciences; reinforcement learning; serotonin; MEDIAL PREFRONTAL CORTEX; DORSAL RAPHE NUCLEUS; VENTRAL TEGMENTAL AREA; PAVLOVIAN-INSTRUMENTAL TRANSFER; ANTERIOR CINGULATE CORTEX; IN-VIVO MICRODIALYSIS; BASOLATERAL AMYGDALA NEURONS; 5-HT2C RECEPTOR ANTAGONISTS; MEDIUM SPINY NEURONS; CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION;

D O I：

10.1038/npp.2010.151

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Affective valence lies on a spectrum ranging from punishment to reward. The coding of such spectra in the brain almost always involves opponency between pairs of systems or structures. There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. In this review, we consider the structure of opponency in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may thus arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition. We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine. Neuropsychopharmacology Reviews (2011) 36, 74-97; doi: 10.1038/npp.2010.151; published online 29 September 2010

引用

页码：74 / 97

页数：24

共 405 条

[111] Prefrontal cortex-nucleus accumbens interaction:: In vivo modulation by dopamine and glutamate in the prefrontal cortex [J].

Del Arco, Alberto ;

Mora, Francisco .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2008, 90 (02) :226-235

[112]

DEUTCH AY, 1992, J NEURAL TRANSM-GEN, P61

[113] PREFRONTAL CORTICAL DOPAMINE SYSTEMS AND THE ELABORATION OF FUNCTIONAL CORTICOSTRIATAL CIRCUITS - IMPLICATIONS FOR SCHIZOPHRENIA AND PARKINSONS-DISEASE [J].

DEUTCH, AY .

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1993, 91 (2-3) :197-221

[114] CONTRIBUTIONS OF ANTERIOR CINGULATE CORTEX TO BEHAVIOUR [J].

DEVINSKY, O ;

MORRELL, MJ ;

VOGT, BA .

BRAIN, 1995, 118 :279-306

[115] Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function:: A combined in vivo electrophysiological and microdialysis study [J].

Di Giovanni, G ;

De Deurwaerdére, P ;

Di Mascio, M ;

Di Matteo, V ;

Esposito, E ;

Spampinato, U .

NEUROSCIENCE, 1999, 91 (02) :587-597

[116] Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies [J].

Di Matteo, Vincenzo ;

Di Giovanni, Giuseppe ;

Pierucci, Massimo ;

Esposito, Ennio .

SEROTONIN-DOPAMINE INTERACTION: EXPERIMENTAL EVIDENCE AND THERAPEUTIC RELEVANCE, 2008, 172 :7-44

[117] Dopamine and serotonin interactions in the prefrontal cortex: Insights on antipsychotic drugs and their mechanism of action [J].

Di Pietro, N. C. ;

Seamans, J. K. .

PHARMACOPSYCHIATRY, 2007, 40 :S27-S33

[118] Dissociation of pavlovian and instrumental incentive learning under dopamine antagonists [J].

Dickinson, A ;

Smith, J ;

Mirenowicz, J .

BEHAVIORAL NEUROSCIENCE, 2000, 114 (03) :468-483

[119] MOTIVATIONAL CONTROL OF GOAL-DIRECTED ACTION [J].

DICKINSON, A ;

BALLEINE, B .

ANIMAL LEARNING & BEHAVIOR, 1994, 22 (01) :1-18

[120]

Dickinson A., 1979, Mechanisms of Learning and Motivation (Erlbaum), P231

← 7 8 9 10 11 12 13 14 15 16 →