Rhodium-catalyzed enantioselective 1,2-addition of aluminum organyl compounds to cyclic enones

被引：36

作者：

Siewert, Juergen ^{[1
]}

Sandmann, Rene ^{[1
]}

von Zezschwitz, Paultheo ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ Chem & Biochem, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 37期

关键词：

1,2-addition; alanes; asymmetric catalysis; enones; rhodium;

D O I：

10.1002/anie.200701087

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A question of the ligand: The chemoselectivity of the rhodium-catalyzed addition of AlMe3 to cyclohex-2-enone is guided by the type of ligand used. Whereas use of an achiral {Rh(cyclooctadiene)} complex leads to a 1,4-addition, use of a {Rh(binap)} species gives highly enantioselective 1,2-additions. This unprecedented reaction can be used for stereoselective 1,2-methylations and arylations of cyclic enones (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7122 / 7124

页数：3

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