Microtechnologies and nanotechnologies for single-cell analysis

被引:172
作者
Andersson, H
van den Berg, A
机构
[1] Univ Twente, BIOS, Lab Chip Grp, MESA Inst, NL-7500 AE Enschede, Netherlands
[2] Royal Inst Technol, Dept Signals Sensors & Syst, S-10044 Stockholm, Sweden
[3] Silex Microsyst AB, S-16440 Kista, Sweden
关键词
D O I
10.1016/j.copbio.2004.01.004
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Many efforts are currently underway to try and mimic the properties of single cells with the aim of designing chips that are as efficient as cells. However, cells are nature's nanotechnology engineering at the scale of atoms and molecules, and it might be better to envision a microchip that utilizes a single cell as an experimentation platform. A novel, so-called laboratory-in-a-cell concept has been described, where advantage is taken of micro-and nanotechnological tools to enable precise control of the biochemical cellular environment; these tools also offer the possibility to analyse the composition of single cells. Methods for single-cell handling and analysis are being developed and will be required for this concept to progress further.
引用
收藏
页码:44 / 49
页数:6
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