Ca2+ microdomains near plasma membrane Ca2+ channels:: impact on cell function

被引:186
作者
Parekh, Anant B. [1 ]
机构
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2008年 / 586卷 / 13期
基金
英国医学研究理事会;
关键词
D O I
10.1113/jphysiol.2008.153460
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In eukaryotic cells, a rise in cytoplasmic Ca2+ can activate a plethora of responses that operate on time scales ranging from milliseconds to days. Inherent to the use of a promiscuous signal like Ca2+ is the problem of specificity: how can Ca2+ activate some responses but not others ? We now know that the spatial profile of the Ca2+ signal is important Ca2+ does not simply rise uniformly throughout the cytoplasm upon stimulation but can reach very high levels locally, creating spatial gradients. The most fundamental local Ca2+ signal is the Ca2+ microdomain that develops rapidly near open plasmalemmal Ca2+ channels like voltage-gated L-type (Cav1.2) and store-operated CRAC channels. Recent work has revealed that Ca2+ microdomains arising from these channels are remarkably versatile in triggering a range of responses that differ enormously in both temporal and spatial profile. Here, I delineate basic features of Ca2+ microdomains and then describe how these highly local signals are used by Ca2+-permeable channels to drive cellular responses.
引用
收藏
页码:3043 / 3054
页数:12
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