共 84 条
Ca2+ microdomains near plasma membrane Ca2+ channels:: impact on cell function
被引:186
作者:
Parekh, Anant B.
[1
]
机构:
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
来源:
JOURNAL OF PHYSIOLOGY-LONDON
|
2008年
/
586卷
/
13期
基金:
英国医学研究理事会;
关键词:
D O I:
10.1113/jphysiol.2008.153460
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
In eukaryotic cells, a rise in cytoplasmic Ca2+ can activate a plethora of responses that operate on time scales ranging from milliseconds to days. Inherent to the use of a promiscuous signal like Ca2+ is the problem of specificity: how can Ca2+ activate some responses but not others ? We now know that the spatial profile of the Ca2+ signal is important Ca2+ does not simply rise uniformly throughout the cytoplasm upon stimulation but can reach very high levels locally, creating spatial gradients. The most fundamental local Ca2+ signal is the Ca2+ microdomain that develops rapidly near open plasmalemmal Ca2+ channels like voltage-gated L-type (Cav1.2) and store-operated CRAC channels. Recent work has revealed that Ca2+ microdomains arising from these channels are remarkably versatile in triggering a range of responses that differ enormously in both temporal and spatial profile. Here, I delineate basic features of Ca2+ microdomains and then describe how these highly local signals are used by Ca2+-permeable channels to drive cellular responses.
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页码:3043 / 3054
页数:12
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