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Proglucagon-derived peptides: Mechanisms of action and therapeutic potential

被引：72
作者：
Sinclair, EM [1 ]
Drucker, DJ
机构：
[1] Toronto Gen Hosp, Dept Med, Banting & Best Diabet Ctr, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00030.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the pepticles for the treatment of human disease.
引用
收藏
页码：357 / 365
页数：9
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