Proglucagon-derived peptides: Mechanisms of action and therapeutic potential

被引：72

作者：

Sinclair, EM ^{[1
]}

Drucker, DJ

机构：

[1] Toronto Gen Hosp, Dept Med, Banting & Best Diabet Ctr, Toronto, ON, Canada

[2] Univ Toronto, Toronto, ON, Canada

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00030.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the pepticles for the treatment of human disease.

引用

页码：357 / 365

页数：9

共 131 条

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