Activity-based protein profiling: From enzyme chemistry

被引：959

作者：

Cravatt, Benjamin F. ^{[1
,2
]}

Wright, Aaron T. ^{[1
,2
]}

Kozarich, John W. ^{[3
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[3] Activx Biosci, La Jolla, CA 92037 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2008年 / 77卷

关键词：

affinity label; mass spectrometry; proteomics;

D O I：

10.1146/annurev.biochem.75.101304.124125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of AMP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.

引用

页码：383 / 414

页数：32

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