Evaluating the role of solvent and borane on the enantioselectivity of the oxazaborolidine reduction of prochiral ketones using catalysts derived from cis-(1R,2S)-1-amino-indan-2-ol

被引：18

作者：

Gilmore, NJ ^{[1
]}

Jones, S ^{[1
]}

机构：

[1] Newcastle Univ, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 15期

关键词：

D O I：

10.1016/S0957-4166(03)00401-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The dependency of the enantioselectivity on the solvent and hydride source for the asymmetric reduction of acetophenone catalysed by the oxazaborolidine derived from cis-(1R,2S)-1-amino-indan-2-ol have been investigated. B-11 NMR studies have implied that monomer/dimer ratios are important for achieving high enantioselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2115 / 2118

页数：4

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