A primer to scaffolded DNA origami

被引：403

作者：

Castro, Carlos Ernesto ^{[1
,2
]}

Kilchherr, Fabian ^{[1
,2
]}

Kim, Do-Nyun ^{[3
]}

Shiao, Enrique Lin ^{[1
,2
]}

Wauer, Tobias ^{[1
,2
]}

Wortmann, Philipp ^{[1
,2
]}

Bathe, Mark ^{[3
]}

Dietz, Hendrik ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Ctr Integrated Prot Sci Munich, Dept Phys, D-8046 Garching, Germany

[2] Tech Univ Munich, Walter Schottky Inst, D-8046 Garching, Germany

[3] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

来源：

NATURE METHODS | 2011年 / 8卷 / 03期

关键词：

FOLDING DNA; SHAPES; NANOPARTICLES; EXONUCLEASE; DESIGN; SYSTEM; ARRAYS;

D O I：

10.1038/NMETH.1570

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular self-assembly with scaffolded DNA origami enables building custom-shaped nanometer-scale objects with molecular weights in the megadalton regime. Here we provide a practical guide for design and assembly of scaffolded DNA origami objects. We also introduce a computational tool for predicting the structure of DNA origami objects and provide information on the conditions under which DNA origami objects can be expected to maintain their structure.

引用

页码：221 / 229

页数：9

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