Polymorphism in carbamazepine cocrystals

被引：224

作者：

Porter, William W., III ^{[1
,2
]}

Elie, Sophia C. ^{[1
,2
]}

Matzger, Adam J. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Macromol Sci & Engn Program, Ann Arbor, MI 48109 USA

来源：

CRYSTAL GROWTH & DESIGN | 2008年 / 8卷 / 01期

关键词：

D O I：

10.1021/cg701022e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN) form of CBZ-NCT, were characterized by Raman spectroscopy and powder X-ray diffraction. CBZ-SAC 11, a new polymorph, was found to be in the monoclinic space group C2/c with a = 35.72 angstrom b = 6.84 angstrom, c = 16.11 angstrom, and beta = 98.03 degrees. The unique feature of CBZ-SAC 11 is the formation of a heterosynthon between the carbamazepine and saccharin. These results are notable because CBZ-NCT and CBZ-SAC are among the most widely studied pharmaceutical cocrystals.

引用

页码：14 / 16

页数：3

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