Synthesis of the C16-C35 fragment of integramycin using olefin hydroesterification reaction as a linchpin

被引：42

作者：

Wang, L ^{[1
]}

Floreancig, PE ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1021/ol036339i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The spiroketal unit of the HIV-integrase inhibitor integramycin has been prepared in an efficient and convergent manner. Key steps in this sequence include the use of ruthenium-mediated hydroesterification reactions of homoallylic alcohols and silyl ethers, and a C,O-dianionic addition into a lactone provides the spiroketal while minimizing protecting group manipulations.

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页码：569 / 572

页数：4

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