Recent advances in different modal imaging-guided photothermal therapy

被引：241

作者：

Chen, Qiwen ^{[1
]}

Wen, Jia ^{[1
]}

Li, Hongjuan ^{[1
]}

Xu, Yongqian ^{[1
]}

Liu, Fengyu ^{[2
]}

Sun, Shiguo ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Shaanxi Key Lab Nat Prod & Chem Biol, Xinong Rd 22, Yangling 712100, Shaanxi, Peoples R China

[2] Dalian Univ Technol, Sch Chem, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116023, Peoples R China

来源：

BIOMATERIALS | 2016年 / 106卷

基金：

中国国家自然科学基金;

关键词：

PTT; Modal imaging; Multi-functional theranostic platforms; Cancer therapy; ENHANCED RAMAN-SCATTERING; REDUCED GRAPHENE OXIDE; RESPONSIVE DRUG CARRIER; NEAR-INFRARED LIGHT; POSITRON-EMISSION-TOMOGRAPHY; UP-CONVERSION NANOPARTICLES; CORE-SHELL NANOCOMPOSITES; PRUSSIAN BLUE NANOCUBES; ONE-POT SYNTHESIS; GOLD-NANOSHELLED MICROCAPSULES;

D O I：

10.1016/j.biomaterials.2016.08.022

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Photothermal therapy (PTT) has recently attracted considerable attention owing to its controllable treatment process, high tumour eradication efficiency and minimal side effects on non-cancer cells. PTT can melt cancerous cells by localising tissue hyperthermia induced by internalised therapeutic agents with a high photothermal conversion efficiency under external laser irradiation. Numerous in vitro and in vivo studies have shown the significant potential of PTT to treat tumours in future practical applications. Unfortunately, the lack of visualisation towards agent delivery and internalisation, as well as imaging-guided comprehensive evaluation of therapeutic outcome, limits its further application. Developments in combined photothermal therapeutic nanoplatforms guided by different imaging modalities have compensated for the major drawback of PTT alone, proving PTT to be a promising technique in biomedical applications. In this review, we introduce recent developments in different imaging modalities including single-modal, dual-modal, triple-modal and even multi-modal imaging-guided PTT, together with imaging-guided multi-functional theranostic nanoplatforms. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：144 / 166

页数：23

共 292 条

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