One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer

被引：179

作者：

Bao, Tao ^{[1
,3
]}

Yin, Wenyan ^{[1
]}

Zheng, Xiaopeng ^{[1
]}

Zhang, Xiao ^{[1
]}

Yu, Jie ^{[1
]}

Dong, Xinghua ^{[1
]}

Yong, Yuan ^{[1
]}

Gao, Fuping ^{[1
]}

Yan, Liang ^{[1
]}

Gu, Zhanjun ^{[1
]}

Zhao, Yuliang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[2] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China

[3] Chengdu Univ Technol, Coll Mat & Chem & Chem Engn, Chengdu 610059, Peoples R China

来源：

BIOMATERIALS | 2016年 / 76卷

基金：

中国国家自然科学基金;

关键词：

Molybdenum oxides; One-pot; Hollow nanospheres; Drug delivery; Theranostics; WALLED CARBON NANOTUBES; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; MOLYBDENUM TRIOXIDE; NANOPARTICLES; OXIDE; LASER; NANOSHEETS; NANOPLATFORM; ABSORPTION;

D O I：

10.1016/j.biomaterials.2015.10.048

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Engineering design of plasmonic nanomaterials as on-demand theranostic nanoagents with imaging, drug carrier, and photothermal therapy (FIT) functions have profound impact on treatment of cancer. Here, a facile 'one-pot' template-free hydrothermal route was firstly developed for synthesis of plasmonic oxygen deficiency molybdenum oxide hollow nanospheres functionalized by poly(ethylene glycol) (PEG-MoO3-x HNSs). The as-prepared PEG-MoO3-x HNSs not only have good biocompatibility but also exhibit obvious localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. Especially, due to its intrinsic mesoporous properties and effective photothermal conversion efficiency upon 808-nm NIR laser irradiation, the PEG-MoO3-x HNSs can be applied as a pH/NIR laser dual-responsive camptothecin (CPT) drug delivery nanoplatform for chemotherapy as well as PTT to cancer cells. A remarkably improved synergistic therapeutic effect to pancreatic (PANC-1) tumor-bearing mice was obtained compared to the result of chemotherapy or PTT alone. Apart from its application for drug delivery, the PEG-MoO3-x HNSs can also be employed as an effective contrast nanoagent for photoacoustic (PAT) imaging because of its high NIR absorption, making it promising as a theranostic nanoagent for PAT imaging-guided chemo-photothermal combinational cancer therapy in the nanomedicine field. (c) 2015 Elsevier Ltd. All rights reserved.

引用

页码：11 / 24

页数：14

共 51 条

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