Conceptual Models of Frailty: The Sarcopenia Phenotype

被引：39

作者：

Afilalo, Jonathan ^{[1
,2
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ, Canada

[2] McGill Univ, Jewish Gen Hosp, Div Clin Epidemiol, Montreal, PQ, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2016年 / 32卷 / 09期

基金：

加拿大健康研究院;

关键词：

SKELETAL-MUSCLE MASS; OLDER-ADULTS; BODY-COMPOSITION; THERAPEUTIC INTERVENTIONS; COMPUTED-TOMOGRAPHY; RANDOMIZED-TRIALS; ELDERLY-PEOPLE; DISABILITY; HEALTH; DEFINITION;

D O I：

10.1016/j.cjca.2016.05.017

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Population aging has redefined cardiovascular medicine toward multifaceted patient-oriented care, with frailty emerging as a fundamental concept. The definition of frailty is ardently debated between opposing constructs: phenotypic criteria and accumulated deficits. Phenotypic criteria revolve around age-related loss of muscle mass and strength, known as sarcopenia. Skeletal muscle is crucial for functioning, mobility, energetics, and is the body's primary reservoir for amino acids. Sarcopenia can be assessed objectively, serving as an incremental predictor of adverse health outcomes and a therapeutic target for muscle-building interventions. Thus, the sarcopenia phenotype should be the central focus of frailty assessment and intervention.

引用

页码：1051 / 1055

页数：5

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