Signalling into the T-cell nucleus: NFAT regulation

被引:123
作者
Masuda, ES
Imamura, R
Amasaki, Y
Arai, K
Arai, N
机构
[1] DNAX Res Inst Mol & Cellular Biol Inc, Dept Cell Signalling, Palo Alto, CA 94304 USA
[2] Univ Tokyo, Inst Med Sci, Dept Mol & Dev Biol, Tokyo 108, Japan
关键词
NFAT; T-cell activation; cytokine expression; signal transduction; transcription;
D O I
10.1016/S0898-6568(98)00019-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The nuclear factor of activated T cells (NFAT) plays an important role in T-cell biology. Activation of T cells results in the rapid calcineurin-dependent translocation of NFAT transcription factors from the cytoplasm to the nucleus. This translocation process coupled to the subsequent active maintenance of NFAT in the nucleus compartment is critical for the induction of expression of several genes encoding cytokines and membrane proteins that modulate immune responses. The molecular cloning of the NFAT family of transcription factors has facilitated rapid progress in the understanding of the signalling mechanisms that control the activity of NFAT. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:599 / 611
页数:13
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