Migration cues induce chromatin alterations

被引：46

作者：

Gerlitz, Gabi

Livnat, Idit

Ziv, Carmit

Yarden, Oded

Bustin, Michael ^{[1
]}

Reiner, Orly

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[2] NCI, Protein Sect, Lab Metab, US NIH, Bethesda, MD 20892 USA

[3] Hebrew Univ Jerusalem, Fac Agr Food & Environm Qual Sci, Dept Plant Pathol & Microbiol, IL-76100 Rehovot, Israel

来源：

TRAFFIC | 2007年 / 8卷 / 11期

关键词：

chromatin; histone H1; histone modifications; migration;

D O I：

10.1111/j.1600-0854.2007.00638.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Directed cell migration is a property central to multiple basic biological processes. Here, we show that directed cell migration is associated with global changes in the chromatin fiber. Polarized posttranslational changes in histone H1 along with a transient decrease in H1 mobility were detected in cells facing the scratch in a wound healing assay. In parallel to the changes in H1, the levels of the heterochromatin marker histone H3 lysine 9 tri-methylation were elevated. Interestingly, reduction of the chromatin-binding affinity of H1 altered the cell migration rates. Moreover, migration-associated changes in histone H1 were observed during nuclear motility in the simple multicellular organism Neurospora crassa. Our studies suggest that dynamic reorganization of the chromatin fiber is an early event in the cellular response to migration cues.

引用

页码：1521 / 1529

页数：9

共 40 条

[1]

p27Kip1-stathmin interaction influences sarcoma cell migration and invasion [J].