MitoP2, an integrated database on mitochondrial proteins in yeast and man

被引：70

作者：

Andreoli, C

Prokisch, H

Hörtnagel, K

Mueller, JC

Münsterkötter, M

Scharfe, C

Meitinger, T

机构：

[1] GSF, Natl Res Ctr Environm & Hlth, Inst Human Genet, D-85764 Neuherberg, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Inst Bioinformat, D-85764 Neuherberg, Germany

[3] Dept Biochem, Palo Alto, CA 94304 USA

[4] Stanford Univ, Genome Technol Ctr, Palo Alto, CA 94304 USA

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The aim of the MitoP2 database (http://ihg.gsf.de/ mitop2) is to provide a comprehensive list of mitochondrial proteins of yeast and man. Based on the current literature we created an annotated reference set of yeast and human proteins. In addition, data sets relevant to the study of the mitochondrial proteome are integrated and accessible via search tools and links. They include computational predictions of signalling sequences, and summarize results from proteome mapping, mutant screening, expression profiling, protein-protein interaction and cellular sublocalization studies. For each individual approach, specificity and sensitivity for allocating mitochondrial proteins was calculated. By providing the evidence for mitochondrial candidate proteins the MitoP2 database lends itself to the genetic characterization of human mitochondriopathies.

引用

页码：D459 / D462

页数：4

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