MitBASE: a comprehensive and integrated mitochondrial DNA database. The present status

被引：19

作者：

Attimonelli, M ^{[1
]}

Altamura, N

Benne, R

Brennicke, A

Cooper, JM

D'Elia, D

de Montalvo, A

de Pinto, B

De Robertis, M

Golik, P

Knoop, V

Lanave, C

Lazowska, J

Licciulli, F

Malladi, BS

Memeo, F

Monnerot, M

Pasimeni, R

Pilbout, S

Schapira, AHV

Sloof, P

Saccone, C

机构：

[1] Univ Bari, Dipartmento Biochim & Biol Mol, I-70126 Bari, Italy

[2] CNR, Ctr Studio Mitocondri & Metab Energet, I-70126 Bari, Italy

[3] Univ Amsterdam, Acad Med Ctr, Vakgrp Biochem, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Ulm, D-89069 Ulm, Germany

[5] Royal Free Hosp, Dept Clin Neurosci, London NW3 2QG, England

[6] CNR, Area Ric, I-70126 Bari, Italy

[7] Univ Cantabria, Hosp Univ Marques de Valdecilla, Dept Biol Mol, Santander 39011, Spain

[8] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[9] EBI Hinxton Hall, Cambridge, England

[10] Inst Neurol, Dept Clin Neurol, London WC1N 3BG, England

来源：

NUCLEIC ACIDS RESEARCH | 2000年 / 28卷 / 01期

关键词：

D O I：

10.1093/nar/28.1.148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects, under a single interface, databases for Plant, Vertebrate, Invertebrate, Human, Protist and Fungal mtDNA and a Pilot database on nuclear genes involved in mitochondrial biogenesis in Saccharomyces cerevisiae. MitBASE reports all available information from different organisms and from intraspecies variants and mutants. Data have been drawn from the primary databases and from the literature; value adding information has been structured, e,g,, editing information on protist mtDNA genomes, pathological information for human mtDNA variants, etc. The different databases, some of which are structured using commercial packages (Microsoft Access, File Maker Pro) while others use a flat-file format, have been integrated under ORACLE. Ad hoc retrieval systems have been devised for some of the above listed databases keeping into account their peculiarities. The database is resident at the EBI and is available at the following site: http://www3.ebi.ac.uk/Research/Mitbase/mitbase.pl. The impact of this project is intended for both basic and applied research. The study of mitochondrial genetic diseases and mitochondrial DNA intraspecies diversity are key topics in several biotechnological fields. The database has been funded within the EU Biotechnology programme.

引用

页码：148 / 152

页数：5

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