A comparison of amino acid sequences of hepatitis B virus S gene in 46 children presenting various clinical features for immunoprophylaxis

被引：13

作者：

Miyake, Y

Oda, T

Li, R

Sugiyama, K

机构：

[1] Department of Pediatrics, Nagoya City Univ. Medical School

[2] Department of Pediatrics, Nagoya City Univ. Medical School, Mizuho-ku, Nagoya 467, Kawasumi-cho

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1996年 / 180卷 / 03期

关键词：

hepatitis B virus; mother-to-child transmission; antibody escape mutant; S gene;

D O I：

10.1620/tjem.180.233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared amino acid sequences of hepatitis B virus (HBV) S protein deduced from analyzed DNA sequence in 46 children who received immunoprophylaxis to prevent mother-to-child transmission of HBV. They were classified into 6 groups by their clinical features. The antibody escape mutants were found in 8 cases among 46 cases. We studied the difference in clinical features in these cases and speculated that 126 Ser or 140 Ser-strain may have a different behavior in relation to antibody to hepatitis B surface antigen from 126 Ban or 145 Arg-strain.

引用

页码：233 / 247

页数：15

共 21 条

[11]

Oda T., 1994, Nagoya Medical Journal, V39, P47

[12] MARKEDLY PROLONGED INCUBATION PERIOD OF HEPATITIS-B IN A CHIMPANZEE PASSIVELY IMMUNIZED WITH A HUMAN MONOCLONAL-ANTIBODY TO THE ALPHA-DETERMINANT OF HEPATITIS-B SURFACE-ANTIGEN [J].