Cell cycle - Mitotic treasures in the nucleolus

被引：38

作者：

Bachant, JB

Elledge, SJ

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem, Houston, TX 77030 USA

来源：

NATURE | 1999年 / 398卷 / 6730期

关键词：

D O I：

10.1038/19641

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

How does a cell regulate its exit from the stage of the cell cycle known as mitosis? The answer, surprisingly, involves a new regulatory principle. Exit, it seems, is controlled by switching off mitotic kinases, and this is done by a phosphatase called Cdc14, an inactive form of which is sequestered in the nucleolus until needed. This is the first time that nucleolar localization has been shown as a regulatory mechanism.

引用

页码：757 / 758

页数：2

共 13 条

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