Cell cycle - Mitotic treasures in the nucleolus

被引：38

作者：

Bachant, JB

Elledge, SJ

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem, Houston, TX 77030 USA

来源：

NATURE | 1999年 / 398卷 / 6730期

关键词：

D O I：

10.1038/19641

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

How does a cell regulate its exit from the stage of the cell cycle known as mitosis? The answer, surprisingly, involves a new regulatory principle. Exit, it seems, is controlled by switching off mitotic kinases, and this is done by a phosphatase called Cdc14, an inactive form of which is sequestered in the nucleolus until needed. This is the first time that nucleolar localization has been shown as a regulatory mechanism.

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收藏

页码：757 / 758

页数：2

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共 13 条

[1] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p [J].

CohenFix, O ;

Peters, JM ;

Kirschner, MW ;

Koshland, D .

GENES & DEVELOPMENT, 1996, 10 (24) :3081-3093

[2] Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1 [J].

Fang, GW ;

Yu, HT ;

Kirschner, MW .

MOLECULAR CELL, 1998, 2 (02) :163-171

[3] A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p [J].

Feldman, RMR ;

Correll, CC ;

Kaplan, KB ;

Deshaies, RJ .

CELL, 1997, 91 (02) :221-230

[4] Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14 [J].

Jaspersen, SL ;

Charles, JF ;

Morgan, DO .

CURRENT BIOLOGY, 1999, 9 (05) :227-236

[5] Cyclin-dependent kinases: Engines, clocks, and microprocessors [J].

Morgan, DO .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :261-291

[6] Yeast Hct1 is a regulator of Clb2 cyclin proteolysis [J].

Schwab, M ;

Lutum, AS ;

Seufert, W .

CELL, 1997, 90 (04) :683-693

[7] Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex [J].

Shou, WY ;

Seol, JH ;

Shevchenko, A ;

Baskerville, C ;

Moazed, D ;

Chen, ZWS ;

Jang, J ;

Shevchenko, A ;

Charbonneau, H ;

Deshaies, RJ .

CELL, 1999, 97 (02) :233-244

[8] F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex [J].

Skowyra, D ;

Craig, KL ;

Tyers, M ;

Elledge, SJ ;

Harper, JW .

CELL, 1997, 91 (02) :209-219

[9] Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus [J].

Visintin, R ;

Hwang, ES ;

Amon, A .

NATURE, 1999, 398 (6730) :818-823

[10] The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation [J].

Visintin, R ;

Craig, K ;

Hwang, ES ;

Prinz, S ;

Tyers, M ;

Amon, A .

MOLECULAR CELL, 1998, 2 (06) :709-718