Wnt signalling: Antagonistic Dickkopfs

被引：198

作者：

Zorn, AM ^{[1
]}

机构：

[1] Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-9822(01)00360-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt-Frizzled-LRP5/6 receptor complexes, thus blocking the canonical Wnt-beta -catenin pathway.

引用

页码：R592 / R595

页数：4

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