A model complex of a possible intermediate in the mechanism of action of peptide deformylase:: first example of an (N2S)zinc(II)-formate complex

被引：30

作者：

Chang, SC

Sommer, RD

Rheingold, AL

Goldberg, DP

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[2] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 22期

关键词：

D O I：

10.1039/b106865m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and crystallographic characterization of a new (N2S) zinc-alkyl complex and (N2S) zinc-formate complex is described; the bonding mode of the formate complex has implications for the mechanism of action of the enzyme peptide deformylase.

引用

收藏

页码：2396 / 2397

页数：2

相关论文

共 15 条

[1] Iron center, substrate recognition and mechanism of peptide deformylase [J].

Becker, A ;

Schlichting, I ;

Kabsch, W ;

Groche, D ;

Schultz, S ;

Wagner, AFV .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (12) :1053-1058

[2] Model complexes of the active site in peptide deformylase:: A new family of mononuclear N2S-M(II) complexes [J].

Chang, SC ;

Karambelkar, VV ;

diTargiani, RC ;

Goldberg, DP .

INORGANIC CHEMISTRY, 2001, 40 (02) :194-+

[3] ROLE OF THE METAL CENTER IN THE HOMOGENEOUS CATALYTIC DECARBOXYLATION OF SELECT CARBOXYLIC-ACIDS - COPPER(I) AND ZINC(II) DERIVATIVES [J].

DARENSBOURG, DJ ;

HOLTCAMP, MW ;

LONGRIDGE, EM ;

KHANDELWAL, B ;

KLAUSMEYER, KK ;

REIBENSPIES, JH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (01) :318-328

[4] STRUCTURE OF COBALT CARBONIC-ANHYDRASE COMPLEXED WITH BICARBONATE [J].

HAKANSSON, K ;

WEHNERT, A .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 228 (04) :1212-1218

[5] Structure and physical properties of several pseudotetrahedral zinc complexes containing a new alkyl thiolate heteroscorpionate ligand [J].

Hammes, BS ;

Carrano, CJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2000, (19) :3304-3309

[6] Structural studies of the [tris(imidazolyl)phosphine]metal nitrate complexes {[PimPri,But]M(NO3)}+ (M = Co, Cu, Zn, Cd, Hg):: Comparison of nitrate-binding modes in synthesis analogues of carbonic anhydrase [J].

Kimblin, C ;

Murphy, VJ ;

Hascall, T ;

Bridgewater, BM ;

Bonanno, JB ;

Parkin, G .

INORGANIC CHEMISTRY, 2000, 39 (05) :967-974

[7] The synthesis and structural characterization of bis(mercaptoimidazolyl)(pyrazolyl)hydroborato and tris(mercaptoimidazolyl)hydroborato complexes of thallium(I) and thallium(III) [J].

Kimblin, C ;

Bridgewater, BM ;

Hascall, T ;

Parkin, G .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2000, (08) :1267-1274

[8] UNIDENTATE VERSUS SYMMETRICALLY AND UNSYMMETRICALLY BIDENTATE NITRATE COORDINATION IN PYRAZOLE-CONTAINING CHELATES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF (NITRATO-O)[TRIS(3,5-DIMETHYLPYRAZOL-1-YLMETHYL)AMINE]COPPER(II) NITRATE, (NITRATO-O,O')(TRIS(3,5-DIMETHYLPYRAZOL-1-YLMETHYL)AMINE]NICKEL(II) NITRATE, AND (NITRATO-O)(NITRATO-O,O')[TRIS(3,5-DIMETHYLPYRAZOL-1-YLMETHYL)AMINE]CADMIUM(II)) [J].

KLEYWEGT, GJ ;

WIESMEIJER, WGR ;

VANDRIEL, GJ ;

DRIESSEN, WL ;

REEDIJK, J ;

NOORDIK, JH .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1985, (10) :2177-2184

[9] A model for ZnII-containing-β-lactamase:: Synthesis, x-ray crystal structure of a zinc(II) complex bearing thiol group and hydrolysis of phosphate diester [J].

Kurosaki, H ;

Tawada, T ;

Kawasoe, S ;

Ohashi, Y ;

Goto, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (12) :1333-1337

[10] Recent advances in zinc enzymology [J].

Lipscomb, WN ;

Strater, N .

CHEMICAL REVIEWS, 1996, 96 (07) :2375-2433