A rapid parallel synthesis of 2-dialkylamino-4H-imidazolin-4-ones

被引：29

作者：

Ding, MW ^{[1
]}

Sun, Y ^{[1
]}

Yang, SJ ^{[1
]}

Liu, XP ^{[1
]}

Liu, ZJ ^{[1
]}

机构：

[1] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 10期

基金：

中国国家自然科学基金;

关键词：

4H-imidazolin-4-ones; Aza-Wittig reaction; parallel synthesis;

D O I：

10.1081/SCC-120018926

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Dialkylamino-4H-imidazolin-4-ones 6 were rapidly synthesized by a solution-phase parallel synthetic method, which includes Aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various aliphatic secondary amine in a parallel fashion.

引用

页码：1651 / 1658

页数：8

共 15 条

[1]

CREMER G, 1995, Patent No. 5457112

[2] Application of carbodiimide in heterocyclic synthesis: New facile synthesis of 2-aminoimidazolinone derivatives [J].

Ding, MW ;

Tu, HY ;

Liu, ZJ .

SYNTHETIC COMMUNICATIONS, 1997, 27 (20) :3657-3662

[3]

DING MW, 1998, CHINESE J ORG CHEM, V18, P572

[4] Solid-phase synthesis of 2-aminoimidazolinones [J].

Drewry, DH ;

Ghiron, C .

TETRAHEDRON LETTERS, 2000, 41 (36) :6989-6992

[5] Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition [J].

Flynn, DL ;

Crich, JZ ;

Devraj, RV ;

Hockerman, SL ;

Parlow, JJ ;

South, MS ;

Woodard, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4874-4881

[6] APLYSINOPSIN-TYPE ALKALOIDS FROM DENDROPHYLLIA SP, A SCLERACTINIAN CORAL OF THE FAMILY DENDROPHYLLIIDAE OF THE PHILIPPINES - FACILE PHOTOCHEMICAL (Z/E) PHOTOISOMERIZATION AND THERMAL REVERSAL [J].

GUELLA, G ;

MANCINI, I ;

ZIBROWIUS, H ;

PIETRA, F .

HELVETICA CHIMICA ACTA, 1989, 72 (07) :1444-1450

[7] Synthesis, conformational analysis and antitumor testing of 5-(Z)-arylidene-4-imidazolidinone derivatives [J].

Khodair, AI ;

El-Subbagh, HI ;

Al-Obaid, AM .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1998, 140 :159-181

[8]

Kiec-Kononowicz K, 1998, PHARMAZIE, V53, P680

[9] A facile and practical solid-phase synthesis of trisubstituted 2-aminoimidazolones [J].

Li, M ;

Wilson, LJ .

TETRAHEDRON LETTERS, 2001, 42 (08) :1455-1458

[10] A new indole alkaloid from the marine tunicate Dendrodoa grossularia [J].

Loukaci, A ;

Guyot, M ;

Chiaroni, A ;

Riche, C .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04) :519-522

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